Antibodies

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Antibodies

Antibodies, also known as immunoglobulins, are indispensable tools in scientific research, serving a multitude of purposes across various disciplines. Due to their remarkable specificity and affinity for target molecules, they have become essential in techniques such as Fluorescence-Activated Cell Sorting (FACS), Western blotting, immunohistochemistry (IHC), and flow cytometry.

In our offering, there are polyclonal and monoclonal antibodies from various species. The polyclonal antibodies are affinity purified.

Coagulation proteins play a crucial role in hemostasis, ensuring proper blood clot formation to prevent excessive bleeding. Antibodies targeting coagulation proteins, such as Factor VIII and Factor IX, are instrumental in elucidating the intricate pathways involved in blood clotting disorders like hemophilia. Through techniques like Western blotting and enzyme-linked immunosorbent assay (ELISA), these antibodies enable researchers to quantitatively analyze the expression levels and post-translational modifications of coagulation factors, shedding light on their physiological functions and dysregulation in disease states.

The immune system comprises a diverse array of cells that orchestrate immune responses to pathogens and maintain homeostasis within the body. Antibodies targeting specific immune cell markers, such as CD3 and CD4 for T cells, CD8 for cytotoxic T cells, CD14 for monocytes and macrophages, CD34 for hematopoietic stem cells (HSCs), and the pan-leukocyte marker CD45, facilitate the identification and characterization of immune cell and progenitor populations using techniques like flow cytometry and immunohistochemistry. These antibodies enable researchers to discern distinct immune cell subsets, monitor immune cell activation and proliferation, and investigate the role of immune cells in various disease contexts, including autoimmunity, cancer, and infectious diseases.

In cell biology research, antibodies serve as indispensable tools for probing cellular structures, signaling pathways, and protein interactions. Antibodies against cytoskeletal proteins, organelle markers, and signaling molecules enable the visualization and localization of specific cellular components using techniques like immunofluorescence microscopy and immunoelectron microscopy. Moreover, antibodies against phosphorylated proteins or protein modifications facilitate the study of dynamic cellular processes and signaling cascades. Techniques such as co-immunoprecipitation and proximity ligation assay (PLA) leverage antibody specificity to elucidate protein-protein interactions and unravel complex molecular networks within cells.