Description
Worthington Collagenase Type 4 is a low-tryptic-activity collagenase preparation designed to help minimize damage to cell-surface proteins and receptors while maintaining normal to above-normal collagenase activity. It is particularly suitable for the isolation of primary pancreatic islets and other applications requiring gentle tissue dissociation.
For a detailed comparison of all collagenase types, their enzymatic activity profiles, and guidance on selecting the right preparation for your application, see the Collagenase Wiki.
For guidance on tissue dissociation and a curated collection of published references — covering a broad range of tissues, cell types, and species — request your Tissue Dissociation Guide.
Available Preparations and Pack Sizes
Collagenase Type 4 is available unfiltered (CLS-4) (see below) and as a 0.22 µm membrane-filtered preparation (CLSS-4) – the filtered version is a standard precaution in primary cell isolation workflows to reduce the risk of contamination.
Preparations are stable for 12 months from date of receipt when stored as recommended.
For a complete overview of all available collagenase preparations and ready-to-use tissue dissociation kits, see our full collagenase portfolio.
Collagenase Services
We offer two dedicated services to help you find the right lot — and keep it:
– Collagenase Sampling Program & Lot Reservation – test two different lots or types and reserve stock while you evaluate.
– Lot Matching Service – find the closest alternative when your preferred lot is no longer available.
Learn more about our Collagenase Services or contact us to discuss your specific requirements — we are happy to help.
