Overview
- Species: Synthetic
- Keywords: 3D Hydrogels
- Specific Attributes: Thermoreversible hydrogel
Mebiol® Thermoreversible Hydrogel
Cat.-Nr.: 5180-10ML
Description
Mebiol® Thermoreversible Hydrogel is 1 gram of a copolymer of poly(N-isopropylacrylamide) and poly(ethylene glycol) (PNIPAAm-PEG). The defining feature of Mebiol® is its temperature reversible sol-gel transition. Chill Mebiol® to turn it into a sol (meaning it handles like a liquid). Heat Mebiol® to turn it into a solid hydrogel. The unique thermoreversible feature allows for extremely easy cell handling. Cultures are seeded into cooled Mebiol® and recovered conveniently by cooling the culture vessel and centrifugation. In the gel state, the highly lipophilic and network structure of the Mebiol® presents an efficient niche for cell proliferation, cell communication, gas and mass exchange, and protection of cells and tissue from shear forces.
Mebiol® is easy to use, non-toxic, 100% synthetic and has high transparency. Published applications include stem cell and pluripotent stem cell culture, expansion, and differentiation, spheroid culture, cell implantation, organ and tissue regeneration, drug delivery and more. Though Mebiol® suppresses fibroblast growth, it has been commercialized as a cell/tissue culture reagent for ES cells, chondrocytes and cancer cells.
SUPPLIER:
Advanced BioMatrix
STATUS:
In Stock
SIZE:
10 ml
References
- Aeby, Elise A., et al. "Microfluidic Hydrogel Hanging‐Drop Network for Long‐Term Culturing of 3D Microtissues and Simultaneous High‐Resolution Imaging." Advanced Biosystems 2.7 (2018): 1800054.
- Sudha, B., et al. "Cultivation of human corneal limbal stem cells in Mebiol gel®-A thermo-reversible gelation polymer." Indian Journal of Medical Research 124.6 (2006): 655.
- Sitalakshmi, G., et al. "Ex vivo cultivation of corneal limbal epithelial cells in a thermoreversible polymer (Mebiol Gel) and their transplantation in rabbits: an animal model." Tissue Engineering Part A 15.2 (2008): 407-415.
- Kataoka, Ken, and Nam-ho Huh. "Application of a thermo-reversible gelation polymer, mebiol gel, for stem cell culture and regenerative medicine." Journal of stem cells & regenerative medicine 6.1 (2010): 10.
- Madhavan, H. N., et al. "A study on the growth of continuous culture cell lines embedded in Mebiol gel." CURRENT SCIENCE-BANGALORE- 87 (2004): 1275-1277.
- PARVEEN, NA, et al. "Intraperitoneal transplantation of hepatocytes embedded in thermoreversible gelation polymer (Mebiol Gel) in acute liver failure rat model." (2008): 275-280.
- Kanda, Kazue, et al. "Eccentric exercise-induced delayed-onset muscle soreness and changes in markers of muscle damage and inflammation." Exercise immunology review 19 (2013).
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