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Home |Products|Cells and Media|AlphaSTEM® Naïve hPSC Medium

AlphaSTEM® Naïve hPSC Medium

Cat.-Nr.: MN01500

Description

AlphaSTEM® Naïve hPSC Medium is a serum-free and feeder-free medium formulated for the generation and expansion of naïve pluripotent stem cells.  Utilizing a naturally occurring growth factor, NME7AB , that is expressed in the earliest days of embryogenesis, AlphaSTEM® Naïve hPSC Medium fully supports the naïve state in human stem cells.  The medium can also be used during reprogramming for high efficient generation of naïve induced pluripotent stem cells.  These cells express pluripotency markers, as well as naïve markers, have two active X chromosomes (female lines) and differentiate down all three germlines.

  • SUPPLIER:

    Minerva Biotechnologies

  • STATUS:

    In Stock

  • SIZE:

    500 ml

  • Overview
  • Related Files
  • References

Overview

  • Species: Other
  • Additional Attributes: Media
  • Specific Attributes: frozen, steril
  • Features:kit -AlphaSTEM™ Basal Medium, AlphaSTEM™ Supplement 1, AlphaSTEM™ Supplement 2

Related Files

Datasheet
Property Rights, Use Restrictions and Limited License

References

  • A Primitive Growth Factor, NME7AB , Is Sufficient to Induce Stable Naïve State Human Pluripotency; Reprogramming in This Novel Growth Factor Confers Superior Differentiation. Carter MG, Smagghe BJ, Stewart AK, Rapley JA, Lynch E, Bernier KJ, Keating KW, Hatziioannou VM, Hartman EJ, Bamdad CC. Stem Cells. 2016 Apr;34(4):847-59. doi: 10.1002/stem.2261.
  • MUC1* ligand, NM23-H1, is a novel growth factor that maintains human stem cells in a more naïve state. Smagghe BJ, Stewart AK, Carter MG, Shelton LM, Bernier KJ, Hartman EJ, Calhoun AK, Hatziioannou VM, Lillacci G, Kirk BA, DiNardo BA, Kosik KS, Bamdad C. PLoS One. 2013;8(3): e58601. doi: 10.1371/journal.pone.0058601.
  • MUC1* is a determinant of trastuzumab (Herceptin) resistance in breast cancer cells. Fessler SP, Wotkowicz MT, Mahanta SK, Bamdad C. Breast Cancer Res Treat. 2009 Nov;118(1):113-24. doi: 10.1007/s10549-009-0412-3.
  • A minimal fragment of MUC1 mediates growth of cancer cells. Mahanta S, Fessler SP, Park J, Bamdad C. PLoS One. 2008 Apr 30;3(4):e2054. doi: 10.1371/journal.pone.0002054.
  • MUC1* mediates the growth of human pluripotent stem cells. Hikita ST, Kosik KS, Clegg DO, Bamdad C. PLoS One. 2008 Oct 3;3(10):e3312. doi: 10.1371/journal.pone.0003312.

RELATED PRODUCTS


  • AlphaSTEM® Differentiation Inducer

  • AlphaSTEM® Naïve iPSC Line, Female

  • AlphaSTEM® Naïve iPSC Line, Male

  • AlphaSTEM® Culture Substrate

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AlphaSTEM® Culture Substrate TARGATT ™ Transgenic Kit (5 microinjections)
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