Overview
- Additional Attributes: Reagents
- Specific Attributes: steril
- Species: Synthetic
AlphaSTEM® Differentiation Inducer
Cat.-Nr.: MD00312
Description
AlphaSTEM® Differentiation Inducer is a synthetic peptide that competitively inhibits the activity of NME7AB, the naturally occurring growth factor in AlphaSTEM® Naive hPSC Medium. AlphaSTEM® Differentiation Inducer is added one time when differentiation is initiated and can be added along with any other reagents used for directed differentiation. This leads to increased efficiency and improved yield during directed differentiation. It also ensures the elimination of residual pluripotent cells.
SUPPLIER:
Minerva Biotechnologies
STATUS:
In Stock
SIZE:
3 x 12 µl
References
- A Primitive Growth Factor, NME7AB , Is Sufficient to Induce Stable Naïve State Human Pluripotency; Reprogramming in This Novel Growth Factor Confers Superior Differentiation. Carter MG, Smagghe BJ, Stewart AK, Rapley JA, Lynch E, Bernier KJ, Keating KW, Hatziioannou VM, Hartman EJ, Bamdad CC. Stem Cells. 2016 Apr;34(4):847-59. doi: 10.1002/stem.2261.
- MUC1* ligand, NM23-H1, is a novel growth factor that maintains human stem cells in a more naïve state. Smagghe BJ, Stewart AK, Carter MG, Shelton LM, Bernier KJ, Hartman EJ, Calhoun AK, Hatziioannou VM, Lillacci G, Kirk BA, DiNardo BA, Kosik KS, Bamdad C. PLoS One. 2013;8(3): e58601. doi: 10.1371/journal.pone.0058601.
- MUC1* is a determinant of trastuzumab (Herceptin) resistance in breast cancer cells. Fessler SP, Wotkowicz MT, Mahanta SK, Bamdad C. Breast Cancer Res Treat. 2009 Nov;118(1):113-24. doi: 10.1007/s10549-009-0412-3.
- A minimal fragment of MUC1 mediates growth of cancer cells. Mahanta S, Fessler SP, Park J, Bamdad C. PLoS One. 2008 Apr 30;3(4):e2054. doi: 10.1371/journal.pone.0002054.
- MUC1* mediates the growth of human pluripotent stem cells. Hikita ST, Kosik KS, Clegg DO, Bamdad C. PLoS One. 2008 Oct 3;3(10):e3312. doi: 10.1371/journal.pone.0003312.
TARGATT ™ Transgenic Kit (5 microinjections)