Adhesion Molecules & Peptides

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Adhesion Molecules & Peptides

Adhesion proteins and adhesion peptides are fundamental components involved in a myriad of biological processes, crucial for cell-cell and cell-matrix interactions, tissue organization, and immune responses. These molecules serve as the glue that holds cells together and facilitates their communication with the extracellular environment.

Adhesion proteins are typically large, multifunctional molecules located on cell surfaces or within the extracellular matrix. They include prominent families such as integrins, cadherins, and selectins. Integrins are transmembrane receptors that connect the extracellular matrix to the cytoskeleton, enabling cells to adhere, migrate, and transmit signals bidirectionally. Cadherins are calcium-dependent adhesion molecules crucial for cell-cell interactions and tissue morphogenesis. Selectins mediate the initial rolling and adhesion of leukocytes to endothelial cells during inflammation and immune responses.

In contrast, adhesion peptides are shorter fragments derived from adhesion proteins or engineered to mimic their adhesive functions. These peptides often contain specific amino acid sequences responsible for binding to receptors or ligands on adjacent cells or the extracellular matrix. Due to their smaller size and defined structures, adhesion peptides offer advantages such as improved stability, specificity, and ease of synthesis compared to their protein counterparts.

The biomedical applications of adhesion proteins and peptides are extensive. In tissue engineering, they play a pivotal role in promoting cell adhesion, proliferation, and differentiation. Adhesion proteins are utilized to functionalize biomaterials and scaffolds, providing cues for cell attachment and tissue regeneration. Adhesion peptides, with their precise targeting capabilities, are employed as bioactive coatings on surfaces to enhance cell adhesion and improve the integration of implanted materials with host tissues.

Furthermore, adhesion peptides have shown promise in drug delivery systems. By conjugating therapeutic agents to adhesion peptides, researchers can enhance targeting specificity, thereby minimizing off-target effects and improving therapeutic efficacy. Additionally, adhesion peptides can be engineered to target specific cell types or tissues, allowing for personalized and targeted drug delivery approaches.

In conclusion, adhesion proteins and peptides are indispensable components of cellular adhesion and tissue organization, with broad implications in biomedicine. While adhesion proteins provide structural integrity and mediate cellular interactions, adhesion peptides offer versatility and specificity in biomedical applications such as tissue engineering and targeted drug delivery. Continued research in this field holds the potential for innovative therapeutic strategies and advancements in regenerative medicine.

  • Clear laboratory vial containing 50 mL of 0.1 mg/ml sterile-filtered Poly-L-Lysine solution, a cationic polymer enhancing cell attachment by promoting electrostatic interactions between negatively charged cell membranes and culture surfaces.

    Poly-L-Lysine Hydrobromide, Solution

    Cat.-Nr: 5048-50ML

    Poly-L-Lysine is a synthetic amino acid chain that is positively charged having one hydrobromide per unit of Lysine. Poly-L-Lysine is widely used as... Read More

  • Screw cap tube containing 0.5 mg/ml human CD14 solution, a receptor involved in innate immunity that supports monocyte activation and adhesion in cell culture applications.

    CD14, Human Recombinant

    Cat.-Nr: 5089-0.1MG

    Human CD14 (monocyte differentiation antigen CD14) is a 375 amino acid, phospholipid anchored cell surface protein. This protein is preferentially... Read More

  • Screw cap tube containing 0.5 mg/ml human CD164 solution, a transmembrane sialomucin that functions as both an adhesion receptor and a cytoprotective molecule, regulating proliferation, adhesion, and migration of hematopoietic progenitor cells and promoting myogenesis by enhancing cell-cell interactions.

    CD164, Human Recombinant

    Cat.-Nr: 5100-0.05MG

    CD164 (Sialomucins) belongs to a heterogeneous group of secreted or membrane-associated mucins that appear to play two key but opposing roles in... Read More

  • Screw cap tube containing 0.5 mg/ml human CD2 solution, used in cell culture applications to support T cell adhesion and activation.

    CD2, Human Recombinant

    Cat.-Nr: 5086-0.1MG

    CD2 is a surface antigen of the human T-lymphocyte lineage that is expressed on all peripheral blood T cells. It is one of the earliest T-cell... Read More

  • Screw cap tube containing 0.1 mg/ml human CD270, recombinant solution

    CD270, Human Recombinant

    Cat.-Nr: 5127-0.1MG

    The protein encoded by human tumor necrosis factor receptor superfamily member 14 ( TNFRSF14, CD270) gene is a member of the TNF-receptor... Read More

  • CD274, Human Recombinant

    CD274, Human Recombinant

    Cat.-Nr: 5126-0.1MG

    Human CD274 (programmed cell death 1 ligand 1) is a cell membrane protein which is involved in the costimulatory signal, essential for T-cell... Read More

  • Screw cap tube containing recombinant human CD276 protein solution.

    CD276, Human Recombinant

    Cat.-Nr: 5123-0.1MG

    The protein encoded by human CD276 gene belongs to the immunoglobulin superfamily, and thought to participate in the regulation of T-cell-mediated... Read More

  • CD40, Human Recombinant

    CD40, Human Recombinant

    Cat.-Nr: 5093-0.1MG

    Human CD40 (TNRRSF5: tumor necrosis factor receptor superfamily member 5, isoform 2) is a 203 amino acid cell surface protein. This protein belongs... Read More

  • Screw cap tube containing 0.5 mg/ml human Vitronectin solution. CD86 protein, expressed by antigen-presenting cells, acts as a ligand for T cell surface proteins CD28 and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), providing critical costimulatory signals essential for T cell activation and immune response regulation.

    CD86, Human Recombinant

    Cat.-Nr: 5096-0.1MG

    Human CD86 gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting... Read More

  • Screw cap tube containing 0.1 mg/ml human CDH13, recombinant solution

    CDH13, Human Recombinant

    Cat.-Nr: 5125-0.1MG

    CDH13 gene encodes a member of the cadherin superfamily. The encoded protein is localized to the surface of the cell membrane and is anchored by a... Read More

  • Screw cap tube containing 0.5 mg/ml human CDH18 solution, a calcium-dependent adhesion protein expressed specifically in the central nervous system, involved in synaptic adhesion, axon outgrowth, and guidance, supporting neuronal cell attachment in culture.

    CDH18, Human Recombinant

    Cat.-Nr: 5090-0.1MG

    Human CDH18 gene encodes a type II classical cadherin from the cadherin superfamily of integral membrane proteins that mediate calcium-dependent... Read More

  • Screw cap tube containing recombinant human CDH3 solution.

    CDH3, Human Recombinant

    Cat.-Nr: 5124-0.05MG

    Human CDH3 gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein... Read More

  • Screw cap tube containing 0.5 mg/ml human E-Cadherin (CD324) Solution for cell culture applications promoting cell attachment and growth.

    E-Cadherin, Human Recombinant

    Cat.-Nr: 5085-0.1MG

    Human E-Cadherin (CDH1) is an 882 amino acid protein (1-23 = signal domain) that belongs to a member of the cadherin super family. The encoded... Read More

  • ICAM2, Human Recombinant

    ICAM2, Human Recombinant

    Cat.-Nr: 5107-0.1MG

    The protein encoded by human ICAM2 gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane... Read More

  • Synthetic peptide PEPTITE-2000 powder provided in a clear glass vial with a screw cap, engineered for enhanced cell attachment via the RGD sequence.

    PEPTITE-2000™, RGD Peptide

    Cat.-Nr: 5020-5MG

    PEPTITE-2000® is a synthetic peptide containing the RGD cell attachment sequence found in fibronectin, vitronectin and many other matrix and serum... Read More

  • Poly-D-Lysine-Powder-100mg-vial

    Poly-D-Lysine Hydrobromide, Powder

    Cat.-Nr: 5174-100MG

    Poly-D-Lysine comes with 100 mg of non-sterile powder. Poly-D-Lysine is a synthetic amino acid chain that is positively charged and widely used as a... Read More

  • Clear laboratory vial containing 50 mL of 0.1 mg/ml sterile-filtered Poly-D-Lysine solution, a cationic polymer enhancing cell attachment by promoting electrostatic interactions between negatively charged cell membranes and culture surfaces.

    Poly-D-Lysine Hydrobromide, Solution

    Cat.-Nr: 5049-50ML

    Poly-D-Lysine is a synthetic amino acid chain that is positively charged and widely used as a coating to enhance cell attachment and adhesion to both... Read More

  • Poly-L-Lysine- Powder-100mg-vial

    Poly-L-Lysine Hydrobromide, Powder

    Cat.-Nr: 5173-100MG

    Poly-L-Lysine comes with 100 mg of non-sterile powder. Poly-L-Lysine is a synthetic amino acid chain that is positively charged and widely used as a... Read More

  • Poly-L-Ornithin-Powder-Vial-100-mg

    Poly-L-Ornithine Hydrobromide, Powder

    Cat.-Nr: 5172-100MG

    Poly-L-Ornithine comes with 100 mg of non-sterile powder. Poly-L-Ornithine is a synthetic amino acid chain that is positively charged and widely used... Read More

  • Clear laboratory vial containing 50 mL of 0.1 mg/ml sterile-filtered Poly-L-Ornithine solution, a cationic polymer that supports cell attachment and promotes cell growth by serving as a precursor for polyamines essential in cell proliferation and differentiation.

    Poly-L-Ornithine Hydrobromide, Solution

    Cat.-Nr: 5058-50ML

    Poly-L-Ornithine is a synthetic amino acid chain that is positively charged having one hydrobromide per unit of ornithine. Poly-L-Ornithine is widely... Read More