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PhotoCol®-RUT, Methacrylated Collagen with Ruthenium Kit

Cat.-Nr.: 5271-1KIT

Description

PhotoCol® Methacrylated Collagen is a photocrosslinkable type I collagen for 3D cell culture and bioprinting.

As the most abundant protein in the body, collagen is a key component for cell culture. Collagen methacrylate can be used as a rapidly self-assembling type I collagen to form cross-linked hydrogels for tissue engineering. It has been used with mesenchymal stem cells, fibroblasts, adipose derived stem cells, epithelial cells, and many more.

Collagen methacrylate is useful for forming scaffolds with varying degree of stiffness, by altering collagen concentration or the dose of UV-light exposure. It is also being extensively characterized for its usefulness in 3D bioprinting (extrusion, inkjet, and photolithographic).

PhotoCol® has been used for created 3D microniches, as well as for 3D bioprinting human corneas.

For an overview of our tunable 3D Hydrogels (photo-crosslinking) (click)

For an overview of our tunable 3D Hydrogels (chemical-crosslinking; click)

SUPPLIER:
Advanced BioMatrix
STATUS:
In Stock
SIZE:
100 mg

Overview

Species: Bovine
Additional Attributes: 3D Hydrogels, Bioinks for 3D Bioprinting, Collagen, Tunable Stiffness Hydrogels
Specific Attributes: methacrylated, steril, Telocollagen/acidic treatment, Type I

Packaging:Kit - PhotoCol®, Photoinitiator

Related Files

Datasheet
Certificate of Origin
Declaration of Material Source

References

Maloney, E. et al. Immersion Bioprinting of Tumor Organoids in Multi-Well Plates for Increasing Chemotherapy Screening Throughput. Micromachines 11, 208 (2020).
Isaacson, A., Swioklo, S. & Connon, C. J. 3D bioprinting of a corneal stroma equivalent. Experimental Eye Research 173, 188–193 (2018).
Kathryn E. Drzewiecki et al, A thermoreversible, photocrosslinkable collagen bio-ink for free-form fabrication of scaffolds for regenerative medicine, TECHNOLOGY (2017).
Drzewiecki, K. E. et al. Methacrylation Induces Rapid, Temperature-Dependent, Reversible Self-Assembly of Type-I Collagen. Langmuir 30, 11204–11211 (2014).
Gaudet, I. D. & Shreiber, D. I. Characterization of Methacrylated Type-I Collagen as a Dynamic, Photoactive Hydrogel. Biointerphases 7, 25 (2012).
Izadifar, Mohammad, et al. "UV-assisted 3D bioprinting of nanoreinforced hybrid cardiac patch for myocardial tissue engineering." Tissue Engineering Part C: Methods 24.2 (2018): 74-88.
Stoecklin, Celine, et al. "A New Approach to Design Artificial 3D Microniches with Combined Chemical, Topographical, and Rheological Cues." Advanced Biosystems (2018): 1700237.
Mazzocchi, Andrea, et al. "Optimization of collagen type I-hyaluronan hybrid bioink for 3D bioprinted liver microenvironments." Biofabrication (2018).
Nguyen, T. U., Watkins, K. E. & Kishore, V. Photochemically crosslinked cell‐laden methacrylated collagen hydrogels with high cell viability and functionality. Journal of Biomedical Materials Research Part A107,1541–1550 (2019).
Mazzocchi, A. et al.Pleural Effusion Aspirate for Use in 3D Lung Cancer Modeling and Chemotherapy Screening. ACS Biomaterials Science & Engineering5,1937–1943 (2019).
Chhetri, A. et al. Cell Culture and Coculture for Oncological Research in Appropriate Microenvironments. Current Protocols in Chemical Biology11,(2019).

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