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Home |Products|Haemostasis & Thrombosis|Coagulation Proteins|Human Factor XIa

Human Factor XIa

Cat.-Nr.: HCXIA-0160

Description

Proteolysis of XI by factor XIIa in the presence of high molecular weight kininogen (HMWK), yields the enzyme factor XIa (1-3). Factor XIa is a serine protease which participates in the intrinsic pathway of coagulation by catalyzing the conversion of factor IX to factor IXa. Because factor XI is a homodimer, the enzyme, factor XIa, is composed of two identical heavy chains (Mr = 50,000), and two identical light chains (Mr = 30,000), all of which are held together by disulfide bonds. This latter property makes factor XIa unique among the serine proteases, since it contains two active sites per molecule (1-3). Factor XIa, like its precursor factor XI, remains in complex with HMWK (4). In complex form, factor XIa/HMWK is capable of activating factor XII to factor XIIa and prekallikrein to kallikrein. Additionally, in the complexed form, factor XIa is less affected by protease inhibitors (5). The major plasma inhibitor of factor XIa is 1-antitrypsin and then to a much lesser extent, antithrombin-III (5,6). While in the complexed form, factor XIa may catalyze the proteolysis of HMWK, yielding a biologically inactive form of HMWK (HMWKi), thus allowing dissociation of the Factor XIa/HMWKi complex. Either free factor XIa or the factor XIa/HMWK complex catalyzes the proteolytic conversion of factor IX to factor IXa. Factor XIa is prepared by activating purified factor XI with factor XIIa. Following activation, factor XIa is purified to homogeneity by a combination of affinity chromatography techniques. The factor XIa is supplied in 50% (vol/vol) glycerol/H2O and should be stored at -20°C. Purity is assessed by SDS PAGE analysis. Activity is determined in a clotting assay using factor XI deficient plasma.

  • SUPPLIER:

    Haematologic TechnologiesProlytix

  • STATUS:

    In Stock

  • SIZE:

    50 µg

  • Overview

Overview

  • Species: Human
  • Factors: Factor XI
  • Keywords: Enzymes (Coagulation)
  • Product Type: Enzymes (Coagulation)
  • Formulation:50% (vol/vol) glycerol/H2O
  • Purity:>95%
  • Localization:Plasma
  • Mode of action:A serine protease that converts factor IX to factor IXa
  • Molecular Weight:160000
  • Extinction Coeff:13,4
  • Specific activity:250-450 units/mg
  • Activity:Specific activity is determined by Factor XI clotting assay (APTT). One unit of activity is equivalent to the factor XI activity in one milliter of normal plasma
  • Structure:two apparently identical heavy chains (Mr~50,000) and two apparently identical light chains (Mr~30,000) held together by disulfide bonds. Each light chain contains a catalytic domain
  • Percent carbohydrate:0%

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Link to: Human Factor XIII Link to: Human Factor XIII Human Factor XIII Link to: Human Factor XI Link to: Human Factor XI Human Factor XI
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