We are here to help   +49 2241 25515 0
  • Shopping Cart Shopping Cart
    0Shopping Cart
  • Products
    • Primary Cells & Culture Media
      • Primary Cells
      • Growth Media
      • Differentiation Media
      • Subculture & Reagents
    • Tissue Dissociation
      • Collagenase & Dispase
      • Papain & Trypsin
      • Elastase & Hyaluronidase
      • Tissue Dissociation Kits
    • Matrix Proteins / Bioprinting
      • Collagen
      • Extracellular Matrix Proteins
      • Tunable Stiffness
      • Adhesion Molecules & Peptides
    • iPSC Research
      • iPSC-Derived Cells
      • MEFs
      • Media & Reagents
      • Services & Products
      • iPSC Lines
    • Other Products
      • Enzymes
      • Natural Proteins
      • Staining Kits
      • Cultureware
    • Cell Signaling
      • Cytokines
      • Chemokines
      • Growth Factors
      • Neurotrophins
      • CD Antigens
    • Molecular Biology
      • DNase & Related Products
      • RNase & Related Products
      • Enzymes & Related Products
    • Antibodies
      • Coagulation
      • Immunology
      • Cell Biology
    • Haemostasis & Thrombosis
      • Coagulation Proteins
      • Factor Deficient Plasmas
      • Bone Related Proteins
      • Fluorogenic Substrates & Inhibitors
      • Sample Collection Tubes
  • Services
  • Brands
  • Company
  • Career
  • News
  • Contact
  • Downloads
    • Portfolio Flyer
  • Menu Menu
Home |Products|Haemostasis & Thrombosis|Fluorogenic Substrates & Inhibitors|Human Alpha-2-Plasmin Inhibitor

Human Alpha-2-Plasmin Inhibitor

Cat.-Nr.: HA2AP-0230

Description

α2 –plasmin inhibitor (α2 -PI) is a single-chain glycoprotein and is one of the major serine proteinase inhibitors circulating in plasma. Physiologically, it is the predominant inhibitor of plasmin and it therefore plays a significant role in the specific inhibition of fibrinolysis. The role of α2 -PI in fibrinolysis is three fold: covalent inhibition of plasmin; interference with the binding of plasminogen to fibrin; and factor XIIIa catalyzed cross-linking of α2-PI to fibrin (1). Rapid inactivation of plasmin proteolytic activity occurs through a two-step process. The inhibitor first forms a reversible complex with plasmin which is sub-sequently followed by the formation of a covalent, enzymatically inactive, complex with the catalytic site in plasmin (2,3). α2-PI also functions by interfering with the binding of plasminogen to fibrin, effectively slowing the activation of plasminogen by fibrin-bound plasminogen activator (4). The interference in binding ultimately delays the initiation of fibrinolysis. Covalent cross-linking of α2-PI to the a-chains of fibrin which is mediated by factor XIIIa, protects crosslinked fibrin clots from plasmin degradation and thereby markedly stabilizes the fibrin clot against fibrinolysis (5). Failure to protect the fibrin clot from rapid dissolution before injured vessels can be restored results in a bleeding tendency described in patients with a deficiency in α2-PI or factor XIII (6,7).

  • SUPPLIER:

    Haematologic TechnologiesProlytix

  • STATUS:

    In Stock

  • SIZE:

    100 µg

  • Overview

Overview

  • Species: Human
  • Keywords: Inhibitors
  • Specific Attributes: Protease Inhibitors
  • Product Type: Inhibitors
  • Formulation:50 mM Potassium phosphate, 7.5 mM KCl, 0.075 mM EDTA, pH 7.4
  • Purity:>95%
  • Localization:Plasma
  • Concentration of plasma:69 µg/ml
  • Mode of action:Inhibits plasmin by forming an irreversible complex with the catalytic active site. Prevents the binding of plasmin to fibrin. Cross-linked by factor XIIIa to fibrin.
  • Molecular Weight:58,700 single-chain (determined from amino acid sequence and 14% carbohydrate) and 67,000 (determined by SDS-PAGE)
  • Extinction Coeff:7,3
  • Structure:Circulates as single chain molecule consisting of 452 amino acids
  • Percent carbohydrate:0%

RELATED PRODUCTS


  • Anti-Human Factor XII

  • Bovine Factor Va

  • Corn Trypsin Inhibitor

  • Human Factor X

  • Imprint
  • Privacy policy
Link to: Human alpha-Thrombin Link to: Human alpha-Thrombin Human alpha-Thrombin Link to: HSAEC, Diseased Human Small Airway Epithelial Cells Link to: HSAEC, Diseased Human Small Airway Epithelial Cells HSAEC, Diseased Human Small Airway Epithelial Cells
Scroll to top Scroll to top Scroll to top