Bone Related Proteins

Osteocalcin, a small, vitamin K-dependent protein plays a multifaceted role in bone health, influencing mineralization, osteoblast differentiation, and insulin secretion. We offer human and bovine osteocalcin. Bovine Osteocalcin is prepared by bone demineralization in EDTA, and ion exchange chromatography. Human osteocalcin is prepared from extracts of acid-demineralized bones, using immunoaffinity chromatography. Both variants exhibit purities exceeding 95%, determined by SDS-PAGE.

Another pivotal protein in bone metabolism research is Osteonectin, also recognized as SPARC (Secreted Protein Acidic and Rich in Cysteine). Our offerings include Osteonectin sourced from bovine bone and human activated platelets. Osteonectin regulates bone metabolism by binding hydroxyapatite to collagen. Homologous proteins have been found in various cell types, primarily involved in extracellular matrix production.

Don’t forget to explore our product portfolio for the corresponding antibodies as well.