Primary Cells & Culture Media

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Isolated Primary Cells and selective Cell Culture Media in Experimental Research

Utilizing isolated primary cells in conjunction with carefully optimized cell culture media aims to replicate in vivo conditions, thereby enhancing the physiological relevance of studying cellular behaviors and responses.

Therefore, primary cell culture is the first choice when interested in:

• Disease Modelling and Mechanistic Studies: Isolated primary cells serve as essential models for studying disease mechanisms and pathophysiology. Cultures of healthy and diseased lung epithelial cells (e.g. bronchial/tracheal, small airway), or immune cells, among others, enable researchers to elucidate the underlying molecular pathways driving diseases such as pathogenesis and dysfunction of epithelial tissues and autoimmune conditions.
• Drug Discovery and Development Studies: Primary cell cultures are invaluable tools in drug discovery, allowing researchers to assess the efficacy, toxicity, and pharmacological properties of candidate compounds in a biologically relevant context.

Primary cell culture systems provide researchers with more physiologically relevant models for studying complex biological processes, disease mechanisms, and drug responses.

3D Culture Models: From Organoids, Co-Culture Systems and Organ-on-a-Chip Technology

Organoid and spheroid cultures as well as co-culture systems represent advanced three-dimensional models that mimic the complexity of tissues and organs in vitro.These approaches result in more complex and physiologically relevant systems compared to traditional monolayer cultures, allowing researchers to study cellular interactions, tissue development, disease mechanisms, and drug responses within a setting that closely mimics in vivo conditions.

Three-dimensional, multilineage human skin models—an area where CellSystems® has historically acquired extensive experience—serve as a basis for the reproduction and study of various skin diseases, as well as their treatment in vitro. Furthermore, these models have significantly advanced research in critical areas such as wound healing, and burn therapy. Additionally, the emergence of Organ-on-a-Chip Technology has provided captivating insights into the complex microenvironment and physiological responses of human organs in vitro. In a recent publication, primary cells, culture media, and extracellular matrix proteins were utilized in a microfluidic two-channel co-culture to shed light on the dynamics of the vaginal microbiome for understanding female reproductive tract health and disease.

For a comprehensive overview about our extracellular matrices, adhesion molecules and bioprinting materials, visit Matrix Proteins & Bioprinting.