Overview
- Species: Human
- Keywords: Collagen, Extracellular Matrix
- Specific Attributes: Type IV
- Product Type: Atelocollagen, Type 4 / IV
- Features: lyophilized
Human Collagen Type IV lyoph.
Cat.-Nr.: 5022-5MG
Description
This Type IV Collagen is isolated from human placenta and is purified using a multi-step process. The product is supplied as a sterile, lyophilized powder containing 5 mg of Type IV collagen per vial.
Type IV Collagen is the primary collagen found in the extracellular basement membranes separating a variety of epithelial and endothelial cells. It is a major component of the dermal-epidermal junction where it is mostly found in the lamina densa. It is a heterotrimeric molecule containing two Alpha 1-like and one Alpha 2-like chains.
Type IV Collagen is typically used as a thin coating on tissue culture surfaces. Specific instructions are found in the Directions for Use. This product is generally used in vitro as a substrate scaffold to enhance cell attachment, adherence and proliferation. Type IV collagen may be used to culture epithelial, endothelial, muscle, nerve and many other cell types. Additionally, this product is suitable for use as a substrate for collagenase assays and positive controls.
SUPPLIER:
Advanced BioMatrix
STATUS:
In Stock
SIZE:
5 mg
References
- References for Type IV Collagen:
- Stanton, Bruce A., et al. "Pseudomonas aeruginosa reduces VX-809 stimulated F508del-CFTR chloride secretion by airway epithelial cells." PLoS One 10.5 (2015): e0127742.
- Kang, Yun Gyeong, et al. "A three-dimensional hierarchical scaffold fabricated by a combined rapid prototyping technique and electrospinning process to expand hematopoietic stem/progenitor cells." Biotechnology letters 38.1 (2016): 175-181.
- Pageau, Steven C., et al. "The effect of stromal components on the modulation of the phenotype of human bronchial epithelial cells in 3D culture." Biomaterials 32.29 (2011): 7169-7180.
- Fulcher, M. Leslie, and Scott H. Randell. "Human nasal and tracheo-bronchial respiratory epithelial cell culture." Epithelial Cell Culture Protocols. Humana Press, Totowa, NJ, 2012. 109-121.
- Sellgren, Katelyn L., et al. "A biomimetic multicellular model of the airways using primary human cells." Lab on a Chip 14.17 (2014): 3349-3358.
- Ozeki, Nobuaki, et al. "Gelatin scaffold combined with bone morphogenetic protein-4 induces odontoblast-like cell differentiation involving integrin profile changes, autophagy-related gene 10, and Wnt5 sequentially in human induced pluripotent stem cells." Differentiation 93 (2017): 1-14.
- Ozeki, Nobuaki, et al. "Differentiation of human skeletal muscle stem cells into odontoblasts is dependent on induction of α1 integrin expression." Journal of Biological Chemistry289.20 (2014): 14380-14391.
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