NUCxyme™ — High-Performance DNA/RNA Nuclease for Nucleic Acid Removal in Research & Bioprocessing

NUCxyme™ is a highly specific, sequence-independent endonuclease that degrades all forms of DNA and RNA — single-stranded, double-stranded, linear, and circular. It hydrolyzes nucleic acids into 3–5 base oligonucleotides with 5’ monophosphate termini, effectively reducing viscosity from cellular extracts and eliminating residual DNA/RNA in complex samples.

Recombinantly produced in Komagataella phaffii, NUCxyme™ is free of animal-derived materials, endotoxins, and proteases — making it highly suitable for sensitive applications in biotechnology and downstream processing.

Key Features

• Exceptional Nuclease Activity
  Rapid and complete digestion of linear and circular forms of ssDNA, dsDNA, and RNA
• High Purity and Safety
  Free from proteases, endotoxins, and animal-derived materials.
• Yeast-Expressed, Recombinant
  Produced in Komagataella phaffii to avoid contaminants found in bacterial or animal-based sources.
• Ready-to-Use Liquid Format
  Supplied in 20 mM Tris-HCl, 2 mM MgCl₂, 20 mM NaCl, pH 8.0 with 50% glycerol.

NUCxyme™ is offered in 25 ku and 100 ku formats. Please contact us for bulk or custom quantities.