Retham™ HIT Antibody

Description

Recombinant HIT Antibody Control for Antigen & Functional Assays
Retham™ HIT Antibody is a recombinant monoclonal antibody engineered to mimic pathogenic heparin-induced thrombocytopenia (HIT) antibodies, providing a standardized positive control for both HIT immunoassays and functional platelet activation assays.

Designed for consistency and performance, Retham™ enables reliable results across assay development, validation, and quality control workflows.

 

Why Choose Retham™ HIT Antibody?
Reproducible Performance

– Monoclonal antibody design minimizes lot-to-lot variability
– Ensures consistency across experiments and laboratories

Dual-Use Across HIT Assays

– Compatible with both:
– HIT antigen assays (e.g., PF4/Polyanion ELISA [both PF4/heparin & PF4/Polyvinyl sulfonate], Latex Immunoturbidimetric Assay [LIA])

– Functional assays (e.g., serotonin release assay, SRA)

Functionally Active HIT Antibody

– Induces platelet activation in functional assays
– Mimics clinically relevant HIT antibody behavior

Broad Platform Compatibility

– Validated across multiple HIT testing platforms
– Supports cross-platform standardization

Quality Control Ready

Ideal for:
– Assay validation
– Routine quality control (QC)
– Proficiency testing programs

Performance Highlights
HIT Antigen Assays

– Positive in HIT immunoassays
– Demonstrates heparin-dependent inhibition, consistent with true HIT antibodies

Functional HIT Assays (SRA)

– Strong platelet activation at low heparin concentrations
– Inhibition observed at high heparin concentrations
– Accurately replicates pathogenic HIT antibody behavior

Recommended Use
Research Use Only (RUO) – Not for diagnostic or therapeutic use

Suggested Starting Concentrations:
– Functional assays (SRA): 25 µg/mL
– Antigen assays: 10 µg/mL
Note: Optimization is recommended based on specific assay conditions.

Applications
Retham™ HIT Antibody is ideal for:

– HIT assay development
– Assay validation and verification
– Quality control programs
– Proficiency testing
– Cross-platform assay standardization
– Platelet activation studies

• SUPPLIER:

  Haematologic TechnologiesProlytix

• STATUS:

  In Stock

• SIZE:

  100 µg