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Home |Products|Matrix Proteins / Bioprinting|Gelin-S® Thiol-modified Gelatin

Gelin-S® Thiol-modified Gelatin

Cat.-Nr.: GS230-5ML

Description

Gelin-S® is thiol-modified gelatin (denatured collagen) and is a component of the HyStem®-C, and HyStem-HP hydrogel kits. Most cells do not grow well on Gelin-S–only hydrogels. Instead, Gelin-S should be used in conjunction with Glycosil® (thiol-modified hyaluronic acid) or Heprasil® (thiol-modified hyaluronic acid with thiol-modified heparin). Reconstituted Gelin-S remains liquid at 15 to 37°C.

The gelatin used to make Gelin-S is from Type A Gelatin, Bloom 250, derived from porcine skin.

Gelin-S® (thiol-modified gelatin) is packaged in 5.0 mL vials containing 50mg. Vials are blanketed by nitrogen and under a slight vacuum.

Store Gelin-S in the original vial, unopened, at -20 °C for up to one year. Do not uncap the Gelin-S vials since they will crosslink in the presence of oxygen. Use a syringe and needle to add DG Water to the vials.

Note: It is recommended to reconstitute each vial in its entirety.

  • SUPPLIER:

    Advanced BioMatrix

  • STATUS:

    In Stock

  • SIZE:

    5 ml

  • Overview
  • Related Files
  • References

Overview

  • Species: Porcine
  • Additional Attributes: HyStem®/hyaluronic acid
  • Specific Attributes: steril

Related Files

Certificate of Origin

References

  • References for HyStem®:
  • Maloney, E. et al.Immersion Bioprinting of Tumor Organoids in Multi-Well Plates for Increasing Chemotherapy Screening Throughput. Micromachines 11, 208 (2020).
  • Gaetani, R., et al. (2015) Epicardial application of cardiac progenitor cells in a 3D-printed gelatin/hyaluronic acid patch preserves cardiac function after myocardial infarction. Biomaterials 61: 339-348. PMID: 17335875.
  • Prestwich, G.D., et al. (2007) 3-D culture in synthetic extracellular matrices: new tissue models for drug toxicology and cancer drug discovery. Adv Enzyme Regul 47: 196-207. PMID: 17335875.
  • Shu, X.Z., et al. (2006) Synthesis and evaluation of injectable, in situ crosslinkable synthetic extracellular matrices for tissue engineering. J Biomed Mater Res A 79: 901-912. PMID: 16941590.
  • Shu, X.Z., et al. (2003) Disulfide-crosslinked hyaluronan-gelatin hydrogel films: a covalent mimic of the extracellular matrix for in vitro cell growth. Biomaterials 24: 3825-3834. PMID: 12818555.
  • Cai, et al. (2005) Injectable glycosaminoglycan hydrogels for controlled release of human basic fibroblast growth factor.Biomaterials, 26, 6054-6067.
  • B. Pike, et al. (2006) Heparin-regulated release of growth factors in vitro and angiogenic response in vivo to implanted hyaluronan hydrogels containing VEGF and bFGF. Biomaterials, 27, 5242–5251.
  • D. Prestwich, et al. (2007) 3-D Culture in Synthetic Extracellular Matrices: New Tissue Models for Drug Toxicology and Cancer Drug Discovery. invited, Adv. Enz. Res., in press (2007).
  • Z. Shu, et al, (2006) Synthesis and Evaluation of Injectable, In Situ Crosslinkable Synthetic Extracellular Matrices (sECMs) for Tissue Engineering. J. Biomed Mater. Res. A, 79A(4), 901-912.
  • Shu, X.Z., et al. (2004) In situ crosslinkable hyaluronan hydrogels for tissue engineering. Biomaterials 25: 1339-1348. PMID: 14643608.
  • Mehra, T.D., et al. (2006) Molecular stenting with a crosslinked hyaluronan derivative inhibits collagen gel contraction. J Invest Dermatol 126: 2202-2209. PMID: 16741511.
  • Shu, X.Z., et al. (2004) Attachment and spreading of fibroblasts on an RGD peptide-modified injectable hyaluronan hydrogel. J Biomed Mater Res A 68: 365-375. PMID: 14704979.
  • Ghosh, K., et al. (2007) Cell adaptation to a physiologically relevant ECM mimic with different viscoelastic properties. Biomaterials 28: 671-679. PMID: 17049594.

RELATED PRODUCTS


  • Mebiol® Thermoreversible Hydrogel

  • HyStem® Thiol-Modified Hyaluronan Hydrogel Kit

  • HyStem®-C Thiol-Modified Hyaluronan and Gelatin Hydrogel Kit

  • HyStem®-HP Thiol-Modified Hyaluronan Hydrogel Kit

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