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Home |Products|Coagulation Proteins|Bovine Lactadherin – ALEXA 647

Bovine Lactadherin – ALEXA 647

Cat.-Nr.: BLAC-ALEXA647

Description

Lactadherin is a widely distributed glycoprotein (~ 50 kDa), which was originally characterized due to its association with milk fat/lipid globule membranes. Synonymous names are PAS-6/7, bovine-associated mucoprotein, BA-46, P47, and MFG-E8. Structural hallmarks of lactadherin are the presence of two epidermal growth factor (EGF) homology domains (with an RGD peptide motif in the second EGF domain), and two C domains sharing homology with the discoidin family of lectin domains including the phospholipid-binding domains of blood clotting factors V and VIII. Lactadherin shows preferential binding to phosphatidylserine (L-form) in a calcium independent manner, and binds more specifically than Annexin V.Purified lactadherin functions as an anticoagulant by blocking phosphatidylserine-containing membrane sites for blood coagulation proteins (10). Fluoresence-labeled lactadherin functions as a sensitive probe for exposed phosphatidylserine on nucleated cells and on stimulated platelets (8, 9) . Lactadherin will bind to membranes that have phosphatidylserine content below the threshold for annexin V binding. Lactadherin is purified from un-pasteurized bovine milk (11).

  • SUPPLIER:

    Haematologic TechnologiesProlytix

  • STATUS:

    In Stock

  • SIZE:

    1 ml

  • Overview

Overview

  • Species: Bovine
  • Additional Attributes: Bone Related Proteins

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